Welcome to the Chemical-Induced Gene Signature (CIGS) database which features the expression patterns of 3,407 genes in two cell lines perturbed by 13,221 compounds (including 11,356 MCE bioactive compounds and 1,865 TCM compounds). This dataset encompasses a total of 93,644 perturbations and 319,045,108 gene expression events. Each compound was profiled in triplicate 24 hours after treatment of human breast cancer cell line MDA-MB-231 cells and HEK293T cells, which was derived from human embryo kidney. The website provides sample information, read counts, and gene expression profiles.
TOOLS
Perturbation-response genes query
Find gene signatures of drug by entering the drug name.
Drug search by single gene
Enter the gene symbol of interest and search for drugs that upregulate or downregulate this gene
Zhangscore Query
Query CIGS for reference perturbagen signatures most similar (or dissimilar) to your samples through ZhangScore methods.
